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60 x 5mg

RAD-140 is a substance from the SARM group that has a very strong anabolic effect and negligible androgenic activity. Its unique property is neuroprotective potential. As a substance from the SARM group, RAD-140 is a safer alternative to anabolic androgenic steroids (AAS) and can be a great complement to the AAS cycle, increasing its effectiveness and reducing side effects.

RAD-140, also known as Testolone, is a compound with a chemical name 2-chloro-4 – (((1R, 2S) -1- [5- (4 = cyanophenyl) -1,3,4-oxadiazol-2-yl] -2-hydroxypropylamino) -3-methylbenzonitrile. This compound belongs to the group of Selective Androgen Receptor Modulators (SARM).


Substances from the SARM group were created for people affected by bone damage and degeneration within the osteoarticular system and suffering from muscle atrophy of various origin. Older people, the group most often struggling with these disorders, are particularly vulnerable to androgenic side effects associated with standard steroid therapy.

To avoid unwanted androgenic effects, a special class of compounds that selectively stimulate androgen receptors (AR) was designed, located primarily in muscles, bones and cartilage tissue. Many SARMs are in the final stages of clinical trials, and their use in human studies has shown that they can potentially replace AAS due to their high efficiency and better safety profile.


The main problem for people looking for safe and low-androgenic alternatives to testosterone was the low oral bioavailability. The bioavailability of RAD-140 after oral administration can reach up to 75%, being a better alternative to painful intramuscular injection.


RAD-140 has documented anabolic properties within the muscle tissue, even at low doses (<1 mg). Its anabolic power is comparable to testosterone propionate. Both substances stimulate androgen receptors, leading to increased production of muscle proteins, and thus allowing faster regeneration and increased potential of the tissue growth.


Comparing with SARMs, RAD-140 is distinguished by an extremely strong anabolic effect on muscle tissue, without adversely affecting the prostate, seminiferous tubules, skin or hair.

RAD-140 shows negligible androgenic potential which is why it is better than testosterone. Its use is therefore not associated with typical testosterone side effects. RAD-140 is not susceptible to the action of the aromatase enzyme, hence it does not cause mood swings, increased water retention or gynecomastia. Another advantage of RAD-140 is, unlike testosterone and other AASs, a relatively good safety profile against the hormonal, lipids or blood morphotic parameters.

RAD-140 appears to be safe for the digestive system even at higher doses, as shown in many studies. There were no changes in liver enzymes, while a decrease in blood lipids was observed, which is beneficial from a cardiovascular health perspective and distinguishes RAD-140 from AAS.


RAD-140 was not shown to cause significant suppression of testosterone secretion in animal model studies. There is a greater risk of lowering endogenous production of this hormone when using high doses (30 mg / day) for a longer period of time (12 weeks and longer).

However, it is worth knowing that the return to the initial testosterone concentration usually occurs spontaneously after stopping the use or with the help of testosterone boosters. In extremely severe cases of HPT axis suppression, clomiphene citrate monotherapy successfully restored the original hormonal parameters.


RAD-140 is a unique substance not only when considering other SARMs, but also among all doping agents. RAD-140 can eliminate unwanted side effects associated with the use of popular, highly invasive agents, such as trenbolone, methanabol or testosterone, while increasing their anabolic properties. This is probably due to RAD-140’s high affinity for androgen receptors in the skin and prostate.

Studies have shown that RAD-140 combined with a short testosterone ester enhanced the effects of muscle tissue anabolism. The results were better than using testosterone alone. It was also noted that as a result of taking this combination of substances, there was a noticeably smaller prostatic hyperplasia. As the experience of users shows, RAD-140 can reduce hair loss and oily skin, even when using such strong androgens as trenbolone.


With age and decreasing endogenous testosterone production, the protective effect of this hormone on the brain decreases, which can lead to neurodegenerative diseases. Preclinical data suggest that RAD-140 may show neuroprotective properties. Incubation of RAD-140 with neurons derived from rat brains resulted in a reduction in mortality of the nerve cells of hippocampus exposed to proapoptotic factors.

RAD-140 can also be a valuable addition to the steroid cycle in which agents with a neurodegenerative effect are being used.


Research indicates the potential use of RAD-140 in the treatment of breast cancer. This compound may block estrogen receptors in the nipples, which results in stopping cancer progression. It is suspected that this agent may reduce the total number of estrogen receptors by suppressing the gene responsible for their production, which is ESR1 (Estrogen Receptor 1).

Anti-estrogen effects will undoubtedly be appreciated by people using doping. This is another mechanism by which RAD-140 minimizes the risk of developing gynecomastia due to excess estrogen. This activity is particularly important in the case of simultaneous use of highly aromatizing agents or the previously mentioned trenbolone. This agent makes it difficult to test the actual level of estradiol (E2) in the body, which in turn makes it impossible to choose the right dose of aromatase inhibitors.

To sum up, RAD-140 is one of the strongest SARMs whose users compare its anabolic potency to taking exogenous testosterone. RAD-140 is an ideal addition for experienced users who simultaneously take AAS to minimize undesirable androgenic effects.

The study:

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