Agmatine Pure

Agmatine Pure is a product containing pure agmatine sulfate in a convenient, powdered form.

Agmatine (4-(aminobutyl)-guanine) – a biogenic amine naturally occurring in the body and a product of L-arginine decarboxylation. Widely associated with the effect of a muscle pump, agmatine can strongly support nervous system functioning, cognitive function improvement, alleviation of depressive symptoms, as well as neuroprotection.

Multidirectional action

Agmatine shows several complex mechanisms of action. It inhibits N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors, and stimulates imidazoline receptors. Depending on the dose, it inhibits or stimulates presynaptic α2-adrenergic receptors. Besides, it may inhibit calcium channels and some serotonin receptors.

Such a large number of molecular targets means that agmatine exerts an impact on many different health aspects.

Neurotransmission and neuromodulation

Due to the multitude of interactions with other neurotransmitters of the nervous system, agmatine is referred to as a neurotransmitter and a neuromodulator. Agmatine is present in various brain structures, especially in the areas of the hippocampus and cortex, and its concentration correlates, among others, with the amount of imidazoline receptors.

Agmatine can cross the blood-brain barrier and thus increase its level in neurons. Such the phenomenon is observed upon exogenous agmatine administration and not by L-arginine supplementation.

Endorphin release and mood improvement

Activation of imidazoline receptors leads to increased secretion of β-endorphin, which is the best known and most active opioid peptide. Endorphins, including β-endorphins, are often called “hormones of happiness”. They reduce pain and improve well-being. It is also believed that endorphins are responsible for the phenomenon of runner’s high, i.e. the euphoric state of joy that appears after prolonged exercise.

Due to its unique effect on well-being, agmatine can act as an antidepressant. Agmatine antidepressant activity was found after the administration of 3 g of the compound per day. The aforementioned effect also results from agmatine’s influence on serotonergic transmission.

Neuroprotective properties

Agmatine exerts neuroprotective properties. The inhibition of NMDA receptors, which are key receptors for the glutamatergic system, prevents glutamate excitotoxicity.

Excessive stimulation of NMDA receptors by glutamic acid triggers a cascade of reactions, leading to the formation of free radicals and damage to the structures of the nervous system. The phenomenon of excitotoxicity plays an important role in the development of neurodegenerative diseases, including Alzheimer’s disease, and may contribute to the development of affective disorders.

Optimization of glutaminergic transmission and inhibition of NMDA receptors is used in pharmacology. Drugs with such the mechanism of action are used, among others, in the treatment of Alzheimer’s disease.

Increase in NO synthesis and muscle pump

Unlike L-arginine, agmatine is not a precursor to the synthesis of nitric oxide (NO). Nevertheless, it affects NO metabolism, mainly via α2-adrenergic receptors, which ultimately leads to the activation of endothelial nitric oxide synthase (eNOS).

NO is responsible for the phenomenon of vasodilation. By expanding the blood vessels, NO improves the blood supply and nutrition of the muscles, which directly contributes to increased efficiency and endurance, as well as provides the desired effect of the muscle pump.
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Sensitization to stimulants

Agmatine has the unique quality to restore sensitivity to stimulants and opioid analgesics. The regular use of these substances may cause tolerance to quickly develop, which will subsequently require the doses to be gradually increased. Agmatine, by blocking NMDA receptors, restores optimal sensitivity and works synergistically with analgesics.

To sum up, Agmatine Pure is a product with multiple applications. It is especially recommended for athletes and physically active people to increase vascularization and exercise capacity of the body, as well as for individuals who want to support many aspects of the functioning of the nervous system and those who have a high tolerance to stimulants.
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Ideal pre-workout

It is worth taking agmatine about half an hour before the planned workout. Apart from the increased muscle pump, agmatine also offers an improvement in well-being and motivation, as well as a reduction in pain intensity, which guarantees high effectiveness of the workout.

Enhancement of the stimulatory effects

Agmatine may turn helpful during a break from using stimulants. It is also a great addition to pre-workout preparations because it protects against developing tolerance to stimulatory substances contained in them. This allows for working out at full capacity. To further support the action of agmatine, it is worth combining it with huperzine A.

What to avoid

Since protein may limit the absorption of agmatine, it is not recommended to be consumed along with a meal containing this macroelement.